More evidence of how to protect your heart piles up every day, amounting to a stack of research thicker than the juiciest, most heart-threatening cheeseburger on a big, fat bun. To protect your heart, you've got to protect your arteries, the blood vessels that carry blood from the heart and also feed the heart muscle oxygen and nutrients.

Arteries are essentially three-layered tubes: the inner endothelium, a middle muscle layer which allows the artery to widen and contract, and an outer layer that encloses and supports the other two. When the lining, which is normally smooth, is damaged, the resulting rough patch develops plaque from LDL cholesterol, and the artery narrows and hardens.

When LDL cholesterol is oxidized into plaque, the resulting damage attracts large immune cells called macrophages which consume the oxidized LDL and get trapped in the developing plaque. Oxidized LDL is also associated with the death of muscle cells in the artery's middle layer (Circulation 2000; 102:2680). Plaque slows blood flow to the heart and can result in angina, chest pain often brought about by exertion. Heart attacks strike when unstable plaque ruptures, triggering blood clotting that blocks blood flow and may kill sections of the heart muscle as it's cut off from oxygen and nutrients.

Foods, like fatty meats, filled with saturated fat, are believed to start this heart-threatening process. Even by age 15, your arteries may be narrowing.

Antioxidant Action
Antioxidants can help keep your arteries functioning smoothly by counteracting LDL oxidation. Lab research has shown that cells in the lining can be protected by natural vitamin E. Eating a diet rich in vegetables, fruits and whole grains is an important step in stocking your antioxidant arsenal. But many heart experts recommend supplementation, a strategy that's been shown to bolster the body's defenses (J Nutr Biochem 2001; 12:388-95).

Vitamins C and E: The Dynamic Duo
Antioxidant allies abound, but two of the most important are vitamin C and natural vitamin E. They work particularly well together because C is effective in the fluid that bathes all cells, while E defangs free radicals in the fatty areas, such as cell membranes. And vitamin C actually recharges vitamin E, increasing E's antioxidant effectiveness.
Each vitamin provides protective benefits on its own. People with Type 2 (adult onset) diabetes who took vitamin E in one study saw drops in cholesterol and glucose and increases in antioxidants, such as superoxide peroxidase, produced by the body itself (Endocr Res 2001; 27:377-86).
For its part, vitamin C has prevented free radical damage in individuals who inhale secondhand cigarette smoke and has improved artery lining function in persons with coronary artery disease (Free Radic Biol Med 2000; 28:428-36; Circulation 1999; 99:3234-40).
When used together, this vitamin dynamic duo provides powerful protection against both LDL oxidation and high blood pressure (Arterioscler Thromb Vasc Biol 2000; 20:2087-93; Hypertension 2000; 36:142-6). They also help keep immune cells from sticking to arterial linings (Circ Res 2000; 87:349).

Fighting Inflammation
Vitamins C and E also seem to prove effective against inflammation that researchers think contributes to heart health.
Research in this area continues, but scientists now believe that inflammation from infections with herpes simplex one, the cold sore virus, and Chlamydia pneumoniae, a respiratory tract bug, can foment heart trouble. Inflammation may slow blood flow to the heart and make clots more likely. Among persons with peripheral arterial disease, blockages in arms and legs, not getting enough vitamin C levels may increase inflammation (Circulation 2001; 103:1863). Vitamin E apparently soothes inflammation by decreasing the release of immune chemicals and calming the immune cells involved in atherosclerosis (Diet and Optimum Health Conference, 5/01, Portland OR). Clot Busters Vitamin E also reduces the risk of clots and lowers the chance of a clot sticking in a vessel. It keeps platelets, cells that cause clotting, from becoming too gooey and breaks up fibrin, a clot-forming protein. Garlic (Allium sativa) also discourages inappropriate clotting. Used medicinally since the beginning of recorded time, the Greek physician Dioscorides thought it could clean the arteries. The ancient faith in garlic's circulatory benefits are supported by modern research. Recent studies have found substances in garlic that keep platelets from clumping together and lower cholesterol. In one study, men with high cholesterol who took garlic extract for five months saw their total cholesterol drop an average of 7% and their LDL drop 10% (J Nutr 2001; 131:989S-93S).