The good news: Depression doesn't have to linger forever. With proper nutrition, lifestyle changes and a revived outlook, you can break through that fog into a sunnier emotional clime.
Women are more likely than men to fall prey to depression throughout their lifetimes, with women being twice as likely as men to experience major depression.

While the greatest risk for both sexes falls at midlife, the gender difference appears early; one in ten teenage girls was found to suffer from major depression in one study (International Journal of Behavioral Development 2004; 28:16-25). What's more, childhood depression leaves a person more susceptible to mood problems in adulthood.

One reason for the gender difference in depression, according to researchers, is that women tend to dwell on depressed feelings to a greater degree than men. Some scientists believe a family history of depression carries greater weight for women. Others theorize that the inner fluctuations of a woman's monthly cycle can leave her susceptible to stresses emanating from the outer world. Studies indicate that almost three-quarters of all premenstrual women experience some level of mood difficulties (Summit on Women and Depression, APA, April 02), and a woman's hormonal ebb and flow may even make her more vulnerable to seasonal affective disorder (SAD), the kind of depression linked to a lack of natural light.

Warning Signs
Not surprisingly, many depressed folks feel sad and lethargic, down on themselves and the world. But in some people, depression is marked by agitation and concentration difficulties, or is accompanied by anxiety. Sleep disturbances-either insomnia or excessive sleepiness-often ensue, and activities that used to provide pleasure lose their appeal.

Breaking depression's grip can do more than just lighten your mood-it may help safeguard your health. Studies suggest depression dampens the immune response and may increase the risks of coronary heart disease and diabetes (Archives of General Psychiatry 2003; 60:1009-14; Circulation 2000; 102:1773; Diabetes Care 2004; 27:129-33).

Origins of Depression
The reasons some people are pulled down by depression's undertow while others are able to stay afloat emotionally are complex, but researchers believe common factors link them all.

One factor that can't be ignored is genetics. "If you are depressed, there is a 25% chance that a first-degree relative-a parent, child or sibling-is also depressed," says Hyla Cass, MD, author of St. John's Wort: Nature's Blues Buster (Avery). Other factors are physical problems and medication side effects. That's why your first step should be a consultation with your health care practitioner (if your moods are especially dark, seek professional assistance as soon as possible).

Life's worries and cares also weigh more heavily on some people than on others. " [N]ot only will certain stressors [adverse events] cause depression as a direct response," notes Dr. Cass, "but they may predispose an individual to future episodes of depression." For example, the end of a relationship when you feel you've lost a lover and been humiliated (and been cheated on) raises your risk of depression (Archives of General Psychiatry 2003; 60:789-96).

The Depressed Brain
When depression hits, brain chemistry shifts. As a result, chemicals known as neurotransmitters, which relay messages between brain cells, go awry. For instance, a neurotransmitter called serotonin-critical to mood control-may decrease, leaving you feeling depressed, anxious, craving certain foods and unable to sleep.

Conversely, "high levels of serotonin are associated with emotional and social stability," according to Dr. Cass. She adds that, in addition, sex hormones such as estrogen and testosterone "affect brain cells directly."

Lifting the Fog
Because the causes of depression are so complex, leaving the darkness behind generally requires opening up several pathways.
Part of feeling better simply lies in believing that you can. Researchers have found that depressed people who feel they have a sense of control over their troubles, do, in fact, have a better chance of recovery (General Hospital Psychiatry 2000; 22(4):242-50).
Finding a community of like-minded folks bolsters your capacity to deal with mood problems. In some cases, time spent with a therapist can be a valuable aid in figuring out what's bothering you.

On the physical side, losing weight can lift your spirits. Among women with severe obesity-itself a depression risk factor-losing weight has led to depression relief (Archives of Internal Medicine 2003; 163:2058-65). Research also indicates that exercise helps brighten dark moods.

Nutritional Uplift
A change in diet, along with certain supplements, can also help dispel depression. The first step on the road to emotional recovery: eat a lot of fresh, organic fruits and vegetables, and stay away from overly refined foods with high levels of sugar.

Omega-3 fatty acids, the kinds found in flax seed and fish, are essential to proper brain function. In several studies, people who took supplemental omega-3s found significant relief from depression.

Key amino acids-the basic units of which proteins are built-serve as starting points for the production of mood-lifting neurotransmitters. In one trial, people who took an amino-acid mix that included tyrosine enjoyed better moods and were happier than people who took amino acids without it (Psychopharmacology (Berlin) Sept 4 2003).

Along with amino acids, the body needs the right vitamins-especially members of the all-important B family-to create depression-fighting brain chemicals. In one study, people with depression who took vitamin B12 improved their chances of recovery (BMC Psychiatry 2003; 3:17).

Another interesting observation: Vitamin B12 and its partners vitamin B6 and folate are essential to keep a protein called homocysteine (known primarily as a cardiovascular hazard) from reaching excessive levels, and people with high homocysteine are twice as likely to be depressed. This has led some researchers to speculate that folate may help keep depression under control (Archives of General Psychiatry 2003; 60:618-26).

Herbs that may help beat back the blues include two that help the body deal with stress, eleuthero (Eleutherococcus senticosus) and schisandra (S. chinensis).

A new diet, a new outlook: With the help of the right nutrients and the right support, you can break the bonds of depression.